How CIDP May Be Making You Fat

CIDP and weight gain don’t seem to be caused by loss of mobility, it seems to be coming from hormonal changes.  

By Shiraz Abbas

CIDP (Chronic inflammatory demyelinating polyneuropathy)  is a neurological condition that involves inflammation in the nerves.

As CIDP worsens, people become less mobile and as a result they are more likely to gain weight. However, people are too quick to blame reduced mobility to weight gain. Remember that exercise plays a minor role in weight loss or weight gain.

Some researchers estimate that it accounts for about 5% of weight loss in an average population.

What seems to be contributing more to weight gain among CIDP patients are hormonal changes due to inflammation in the body. Take leptin resistance as one case in point.

cidp treatment

Leptin is the hormone that tells your body that its full. You will notice that when you wake up in the morning you’re not hungry, that’s because your body is high in leptin. Leptin resistance means that your body is resisting the hormone and as a result, you don’t feel full and hence eat more frequently in higher amounts.

So how does this work?

Synchro Life writes that

When leptin is functioning properly in the body, fat storage happens at healthy levels and appetite is consistent with the calories and nutrients the body actually requires.  When cells become resistant to leptin, not only does appetite increase (leading to higher caloric intake), but the calories we eat are stored as fat at a higher rate.  As you might expect, leptin resistance is found nearly universally in obese people.  Even in a non-obese person, how well our cells respond to leptin is a primary determining factor in how easy or difficult it is for us to maintain our desired body composition

As a result,

Research has shown us that leptin resistance directly correlates with chronic inflammation.  One of the primary proteins involved in the inflammatory response in the cell (C-reactive protein) appears to physically interact with leptin inside and outside of the cell, leading to increased leptin resistance.

Leptin resistance is not easy to tackle. But one way to reduce it is through intermittent fasting, good sleep and reduced carbohydrates, all of which can help decrease leptin resistance.

Shiraz Abbas is the founder and manager of the CIDP Neuropathy Support Group. He is also one of the main community educators of IVIG therapy. He resides in Fresno, California. Shiraz can be contacted through our free CIDP advice service at 1-855-782-0574.

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