How CIDP Inflammation May Be Interrupting Neurogenesis
Chronic inflammatory disorders may be linked to the decline of neurons in the brain and possibly lead to depression and other emotional and mental disorders.
By Shiraz Abbas
Up until recently, we believed that all our neurons in our brains were present in childhood and we did not produce any in adulthood. However, in the last few years we have discovered that the body does indeed produce neurons up until the day we die.
The production of neurons in our brains is called neurogenesis. Neurogenesis is important as it has been directly linked with reduction in depression and anxiety. Neurogenesis is also important for intelligence and cognitive function such as concentration and memory.
However, there are cases in which neurogenesis is reduced or stopped completely. For example, cancer drugs can interrupt the process of neurogenesis which is why people with no history of depression are often diagnosed with clinical depression after taking these drugs. Recall that interruption or reduction in neurogenesis has been strongly linked to depression.
A 2003 experiment on rats showed that when they were induced with inflammation, there was a significant reduction in neuron production in their hippocampuses which is where neurogenesis occurs.
A 2015 study showed that interruption in neurogenesis due to inflammation was linked to the development of psychiatric disorders and cognitive function.
A 2018 study has shown that the interruption of neurogenesis due to inflammation also reduces brain plasticity:
Neurogenesis, associated with synaptic plasticity and memory formation, has been linked to the pathogenesis of psychiatric disorders such as depression. Recently, evidence has emerged to suggest that inflammation and the immune system can influence the way neurogenesis occurs in the brain. Specifically, expression levels of cytokines have been shown to modulate cell proliferation, differentiation, and neurogenesis in specific areas of the brain, in particular, the hippocampus.
If you have CIDP, know that you have a chronic inflammatory disorder. Many people with CIDP report depression and other psychiatric disorders. It is possible that CIDP may be associated with the reduction or interruption of neurogenesis in the brain and thereby be linked to the onset of depression.
There are some possible ways to reverse interruption in neurogenesis. These include high fiber diets, exercise, proper sleep and meditation exercises.
If you are facing symptoms of depression or other cognitive difficulties, you may want to consult with your neurologist and see if he or she would recommend you for a psychiatric evaluation.
Shiraz Abbas is the founder and manager of the CIDP Neuropathy Support Group. He is also one of the main community educators of IVIG therapy. He resides in Fresno, California. Shiraz can be contacted through our free CIDP advice service at 1-855-782-0574.