Pre-Medications Reduces Side-Effects of IVIG
IVIG side-effects do happen but not serious. Intravenous immune globulin (IVIG) preparations are safe and effective treatments for CIDP neuropathy or Chronic inflammatory demyelinating polyneuropathy, and other medical conditions. Serious, but uncommon reactions occur, and include thromboembolic events, (e.g., pulmonary embolism, deep vein thrombosis, myocardial infarction, transient ischemic attack), renal dysfunction and acute renal failure. Mild to moderate side effects that occur during or after IVIG treatment are more common. These may include: headache, flushing, chills, myalgia, fatigue, low grade fever, changes in blood pressure and lower back pain. While many common side effects may be controlled by decreasing the IVIG infusion rate, administering physician-prescribed pre-medications can minimize or eliminate side effects and is a common practice. Of note, these reactions can occur with subcutaneous immune globulin (SCIG) but the risk appears to be much lower as compared to IVIG. Patients experiencing unmanageable IVIG side effects may better tolerate SCIG. Subcutaneous site reactions are the common SCIG side effects.
Neuropathy can be treated and sometimes cured with IVIG treatment.